What does Hepatitis B Xiao Sanyang mean?
Hepatitis B small triple positive is a state of hepatitis B virus infection, which usually refers to the simultaneous positivity of three indicators: hepatitis B surface antigen (HBsAg), hepatitis B e-antibody (HBeAb), and hepatitis B core antibody (HBcAb). This state indicates that the hepatitis B virus replication activity in the patient's body is low and the infectivity is weak, but regular monitoring and scientific management are still required. The following is a detailed analysis of the minor three positive aspects of hepatitis B:
1. Clinical significance of small three yang in hepatitis B
Small three yang of hepatitis B is a stage in the natural course of hepatitis B virus infection, which may be transformed from "big three yang" (HBeAg positive). Its clinical features include:
| project | illustrate |
|---|---|
| Viral replication level | Usually low, but some patients still have viral mutations leading to occult replication |
| contagious | Weak, mainly transmitted through blood, mother-to-child and sexual contact |
| risk of liver damage | Still need to be vigilant, about 20%-30% may develop liver fibrosis or cirrhosis |
2. Diagnostic criteria for hepatitis B minor three yangs
The diagnosis of small three positive hepatitis B mainly relies on the results of five hepatitis B tests (two and a half for hepatitis B). The specific indicators are as follows:
| Test items | result | significance |
|---|---|---|
| HBsAg | Positive | Signs of current infection |
| HBsA | Negative | Signs of weakened viral replication |
| HB | Positive | Immune system responds to e antigen |
| HBcAb | Positive | Signs of past or current infection |
3. Precautions for hepatitis B and small yang
1.Regular inspection: Review liver function, HBV-DNA, ultrasound and alpha-fetoprotein every 3-6 months
2.lifestyle: Avoid drinking alcohol, staying up late and overexertion
3.drug treatment: Decide whether to take antiviral treatment according to doctor’s advice (such as HBV-DNA positive and abnormal liver function)
4.Infection prevention: Family members should be vaccinated and avoid sharing items such as razors
4. Principles of treatment of small three yangs of hepatitis B
| Treatment indications | treatment plan |
|---|---|
| HBV-DNA positive and persistent abnormal ALT | First-line antiviral drugs such as entecavir/tenofovir |
| Have a family history of cirrhosis/liver cancer | More aggressive treatment strategies |
| Simple carrying state | Regular observation without treatment |
5. Common misunderstandings about hepatitis B and small positive factors
1.Misunderstanding 1: "Small three yangs are safer than major three yangs" - In fact, some patients with small three yangs still have a significant risk of liver damage
2.Misunderstanding 2: "No need for regular check-ups" - Liver cancer can occur inadvertently
3.Misunderstanding 3: "Can be completely cured" - It is not yet possible to completely remove cccDNA
6. Latest research progress (hot spots in the past 10 days)
1.gene editing technology: CRISPR shows the potential to eliminate HBV in animal experiments (June "Nature" sub-issue)
2.New drug research and development:TLR8 agonist GS-9688 enters phase II clinical trials
3.clinical management: The latest WHO guidelines emphasize strengthening surveillance of infected people over 30 years old
Summary: Hepatitis B minor three positives need to be managed scientifically, and neither excessive panic nor taking it lightly is allowed. It is recommended that patients establish exclusive health files, maintain long-term follow-up with specialists, pay attention to psychological adjustment, and maintain an optimistic attitude.
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